The Accumulation of Lipids in Krabbe DiseaseWhich of the following lipids accumulate in Krabbe disease? Ceramide Sphingosine Galactosphingosine Galactosylceramide

Which of the following lipids accumulate in Krabbe disease?
Ceramide
Sphingosine
Galactosphingosine
Galactosylceramide
Krabbe disease, also known as globoid cell leukodystrophy, is a rare genetic disorder that affects the nervous system. It is caused by a deficiency in the enzyme galactocerebrosidase, which is responsible for breaking down certain lipids, including ceramide, sphingosine, galactosphingosine, and galactosylceramide (Kumar & Dutta, 2020). As a result of this deficiency, these lipids accumulate in the body, leading to damage of the myelin sheath that surrounds and protects nerve cells.
It is well established that the accumulation of these lipids is a key feature of Krabbe disease (Brennen et al., 2018). In particular, ceramide and galactosylceramide are the lipids most commonly found to accumulate in patients with Krabbe disease (Tian et al., 2021). Sphingosine and galactosphingosine have also been identified as lipids that accumulate in Krabbe disease, although to a lesser extent (Moreau et al., 2016).
In summary, ceramide, sphingosine, galactosphingosine, and galactosylceramide are all lipids that accumulate in Krabbe disease. The accumulation of these lipids is a key feature of the disorder and is the result of a deficiency. Cont….